Hydrochloric Acid → HCID 11220404, 화합물

HRID 989898노트

반응식

HRID 989898 반응식
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)=[O:4].[Li+].[I-].Cl>N1C=CC=CC=1>[C:3]([C:5]1[N:6]=[C:7]([CH2:10][CH:11]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[O:8][CH:9]=1)([OH:4])=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 66321Lithium iodideHCID 23389069Ethyl (+/-)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate

생성물 1

HCID 11220404HCID 11220404, 화합물수율 80.5%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of ethyl (±)-4-(4-methoxycarbonyl-1,3-oxazol-2-yl)-3-phenylbutanoate (267 mg, 0.84 mmole) and LiI (338 mg, 2.52 mmole) in pyridine (5 mL) was heated to reflux. After 18 hr, the mixture was cooled to RT, poured into 10% HCl (150 mL), then extracted with CH2Cl2 (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated to give the title compound (205 mg, 80%) as a white solid: MS (ES) m/e 304 (M+H)+.

후처리

  1. extractionextracted with CH2Cl2 (3×50 mL)
  2. dry with materialThe combined organic extracts were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5588958b415d4be39f7d8d9071022f4e
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458814B1

반응 노트

불러오는 중…