Water → Pyridine-2-carbaldehyde thiosemicarbazone
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=O.[NH2:9][NH:10][C:11]([NH2:13])=[S:12].O>C(O)C.O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:9][NH:10][C:11]([NH2:13])=[S:12]참가 물질
5
실험 절차
The corresponding pyridine-2-formaldehyde (23, 23a or 28a-k, 10 mmol) was dissolved in ethanol-water (2:1 v/v, 150 mL). To the solution was added thiosemicarbazide (11 mmol). The solution was stirred for 30 min at ambient temperature. After addition of water (50 mL), the reaction mixture was stirred vigorously for 2 h at room temperature. The yellow precipitate was collected by filtration, washed with ethanol-water (1:4 v/v) and dried in vacuum to afford the corresponding pyridine-2-carboxaldehyde thiosemicarbazone (24, 24a, 29a-k).
후처리
- stirringthe reaction mixture was stirred vigorously for 2 h at room temperature
- filtrationThe yellow precipitate was collected by filtration
- washwashed with ethanol-water (1:4 v/v)
- customdried in vacuum
출처 및 근거
- ORD 기록
- ord-1e741fe4ece3468793eb6392e14c75a3
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06458816B1
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