Anthranilic Acid → Benzoic acid, 2-(((4-methylphenyl)sulfonyl)amino)-

HRID 990108

반응식

HRID 990108 반응식
C(=O)([O-])[O-].[Na+].[Na+].[C:7]([OH:16])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[NH2:10].[C:17]1([CH3:27])[CH:22]=[CH:21][C:20]([S:23](Cl)(=[O:25])=[O:24])=[CH:19][CH:18]=1.Cl>O>[CH3:27][C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:10][C:9]2[C:8](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]([OH:16])=[O:15])(=[O:25])=[O:24])=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 227Anthranilic AcidHCID 313Hydrochloric AcidHCID 73974-Toluenesulfonyl chlorideHCID 10340Sodium Carbonate

생성물 1

HCID 22763Benzoic acid, 2-(((4-methylphenyl)sulfonyl)amino)-

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 3.45 g (25 mmol) of sodium carbonate and 1.0 g (7.3 mmol) of anthranilic acid in 50 ml of water at 60° was treated with 2.09 g (10.95 mmol) of p-toluenesulfonyl chloride and held at 70° for 30 min. The reaction mixture was cooled to ambient temperature and acidified with 10% HCl. After standing for 18 hr the product was collected by filtration, washed with water and dried to give N-4-methylphenylsulfonylanthranilic acid as a solid, mp 226-229°.

후처리

  1. waitAfter standing for 18 hr
  2. filtrationthe product was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-8ea78ecd93754de4ba3e88942421c7d1
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458845B1

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