Hydrochloric Acid → 1,1-Bis(4-hydroxyphenyl)-2,2-dichloroethylene

HRID 990301

반응식

HRID 990301 반응식
[OH-].[K+].[Cl:3][C:4]([Cl:24])=[C:5]([C:15]1[CH:20]=[CH:19][C:18]([O:21]C#N)=[CH:17][CH:16]=1)[C:6]1[CH:11]=[CH:10][C:9]([O:12]C#N)=[CH:8][CH:7]=1.ClC(Cl)(Cl)C(C1C=CC(O)=CC=1)C1C=CC(O)=CC=1.Cl>O.CO>[Cl:3][C:4]([Cl:24])=[C:5]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:6]1[CH:7]=[CH:8][C:9]([OH:12])=[CH:10][CH:11]=1

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 763021,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethaneHCID 112212271,1-Dichloro-2,2-bis(4-cyanatophenyl)ethylene

생성물 1

HCID 846771,1-Bis(4-hydroxyphenyl)-2,2-dichloroethylene

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
20 °C

실험 절차

A 4-necked 5-liter flask, equipped with a mechanical stirrer, a thermometer, and a condenser, is charged with methanol (800 g). Potassium hydroxide (440 g) is added in portions to the methanol solution. After the addition, the solution is cooled to 20° C. To this stirring solution, 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (420 g) is added in portions. The reaction temperature is kept below 40° C. After the addition, the temperature is raised to 50° C. and maintained for 2.5 hours. The reaction mixture is cooled to 20° C. and neutralized with 25% HCl solution. After the neutralization, the mixture is heated to reflux and water (480 g) is added. The mixture is allowed to cool to the room temperature. The precipitates are filtered and dried to afford 1,1-dichloro-2,2-bis(4-hydroxyphenyl)ethene as white solids with slight tan color.

후처리

  1. customA 4-necked 5-liter flask, equipped with a mechanical stirrer
  2. additionAfter the addition
  3. customis kept below 40° C
  4. additionAfter the addition
  5. temperaturethe temperature is raised to 50° C.
  6. temperaturemaintained for 2.5 hours
  7. temperatureAfter the neutralization, the mixture is heated
  8. temperatureto reflux
  9. temperatureto cool to the room temperature
  10. filtrationThe precipitates are filtered
  11. customdried

출처 및 근거

ORD 기록
ord-8539d6fe77a14cb59100a08c2748cce0
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06458993B1

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