Diethylene Glycol Monoethyl Ether → Amitriptyline ketamine

HRID 990584

반응식

HRID 990584 반응식
[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl.[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=2[CH2:32][CH2:31][C:30]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]1=2)[CH3:20].Cl.CCOCCOCCO>>[CH3:18][N:19]([CH2:21][CH2:22][CH:23]=[C:24]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:30]=2[CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][C:34]1=2)[CH3:20].[CH3:1][NH:2][C:3]1([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:15]=2[Cl:16])[C:8](=[O:9])[CH2:7][CH2:6][CH2:5][CH2:4]1

참가 물질

4

반응물 3

HCID 8146Diethylene Glycol Monoethyl EtherHCID 11065Amitriptyline Hydrochloride2회HCID 15851Ketamine Hydrochloride2회

생성물 1

HCID 9892707Amitriptyline ketamine

실험 절차

0.3750 gm ketamine hydrochloride USP and 0.750 gm amitriptyline hydrochloride USP are combined and wetted with 2.0 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. The cream-type mixture contains ketamine hydrochloride at 5 mg/ml and amitriptyline hydrochloride at 10 mg/ml.

출처 및 근거

ORD 기록
ord-e770c9deff2d4242b4c06fba70b039da
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06461600B1

연결된 노트

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