Miconazole Nitrate → Miconazole

HRID 990888

반응식

HRID 990888 반응식
C(O)(=O)CCCCCCCCCCC/C=C\CCCCCCCC.[CH:25]1[C:30]([Cl:31])=[CH:29][C:28]([Cl:32])=[C:27]([CH2:33][O:34][CH:35]([C:42]2[CH:43]=[CH:44][C:45]([Cl:49])=[CH:46][C:47]=2[Cl:48])[CH2:36][N:37]2[CH:41]=[N:40][CH:39]=[CH:38]2)[CH:26]=1.[N+]([O-])(O)=O>>[CH:25]1[C:30]([Cl:31])=[CH:29][C:28]([Cl:32])=[C:27]([CH2:33][O:34][CH:35]([C:42]2[CH:43]=[CH:44][C:45]([Cl:49])=[CH:46][C:47]=2[Cl:48])[CH2:36][N:37]2[CH:41]=[N:40][CH:39]=[CH:38]2)[CH:26]=1

참가 물질

3

반응물 2

HCID 68553Miconazole NitrateHCID 5281116Erucic Acid2회

생성물 1

HCID 4189Miconazole

실험 절차

A vaginal suppository comprising erucic acid, beeswax, and the medicine miconazole was prepared as follows: About 12.30 kg of micronized miconazole nitrate was added to a homogenous melt containing about 62.10 kg of erucic acid and about 6.90 kg of beeswax at a temperature of about 75° C. The medicine and suppository base was mixed gently until homogenous then poured into a mold. Upon cooling the suppository was removed from the mold.

후처리

  1. additionThe medicine and suppository base was mixed gently until homogenous
  2. additionthen poured into a mold
  3. temperatureUpon cooling the suppository
  4. customwas removed from the mold

출처 및 근거

ORD 기록
ord-f883f6771dc7411d8bccb6ef72bd2ff1
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06462083B1

연결된 노트

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