Hydrazine hydrate (1:1) → 4-(1,4-Dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid
반응식
O=[C:2]1[C:10]2([CH:12]([C:13]3[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=3)O2)[CH2:9][C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.O.[NH2:23][NH2:24]>C(O)(=O)C.CO>[NH:23]1[C:2]2[C:3]3[C:8]([CH2:9][C:10]=2[C:12]([C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=[O:18])=[CH:15][CH:14]=2)=[N:24]1)=[CH:7][CH:6]=[CH:5][CH:4]=3참가 물질
5
실험 절차
4-(1-Oxospiro[indan-2,2′-oxiran]-3′-yl)benzoic acid from Example 7b (780 mg), methanol (50 ml), hydrazine hydrate (0.18 ml) and glacial acetic acid (6 drops) were boiled under reflux for 24 hours. The mixture was cooled in ice and filtered to give 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)benzoic acid, m.p. >320° C.
후처리
- temperatureunder reflux for 24 hours
- temperatureThe mixture was cooled in ice
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-0bdea34b53e84a23825daca7849a9092
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06462036B1
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