Lithium Hydroxide → 2-(4-Chlorophenyl)-2-hydroxypropanoic acid
반응식
C([O:3][C:4](=[O:15])[C:5]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=1)([OH:7])[CH3:6])C.[OH-].[Li+]>O1CCCC1.O>[Cl:14][C:11]1[CH:10]=[CH:9][C:8]([C:5]([OH:7])([CH3:6])[C:4]([OH:15])=[O:3])=[CH:13][CH:12]=1참가 물질
5
실험 절차
A solution of 5.72 g of the 2-(4-chlorophenyl)-2-hydroxy propionic acid ethyl ester in 170 ml tetrahydrofurane is hydroysed at 0° C. with a solution of 30.5 ml 1N lithiumhydroxide in 19 ml water. When the reaction is complete, the reaction mixture is diluted with water, washed with diethyl ether, acidified with 1N HCl and extracted with ethyl acetate. The extracts are washed with brine, dried over sodium sulfate and evaporated to give 2-(4-chlorophenyl)-2-hydroxy propionic acid.
후처리
- washwashed with diethyl ether
- extractionextracted with ethyl acetate
- washThe extracts are washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-66ebd3e304814a6a93b3c2cd8d8d5741
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06469005B1
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