Diethyl Malonate → 1,3-Diethyl 2-(1-methylbutyl)propanedioate

HRID 992837

반응식

HRID 992837 반응식
[Na].[C:2]([O:10][CH2:11][CH3:12])(=[O:9])[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].Br[CH:14]([CH2:16][CH2:17][CH3:18])[CH3:15]>C(O)C>[CH2:11]([O:10][C:2](=[O:9])[CH:3]([CH:14]([CH3:15])[CH2:16][CH2:17][CH3:18])[C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:12]

참가 물질

5

반응물 3

HCID 7761Diethyl MalonateHCID 78902-BromopentaneHCID 5360545Sodium

생성물 1

HCID 954491,3-Diethyl 2-(1-methylbutyl)propanedioate수율 67.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Sodium metal (5.24 g, 0.23 g atm) was reacted with 25 mL of absolute ethanol. To this solution was added dropwise, with stirring, diethyl malonate (36.0 mL, 0.24 mol). The solution was heated to reflux and 2-bromopentane (29.0 mL, 0.23 mol) was added dropwise. After refluxing overnight, the reaction was cooled and the ethanol removed on a rotovap. The product was washed with water, dried with MgSO4 and fractionally distilled to give 35.7 g of the desired product.

후처리

  1. additionTo this solution was added dropwise
  2. temperatureThe solution was heated
  3. temperatureto reflux
  4. temperatureAfter refluxing overnight
  5. temperaturethe reaction was cooled
  6. customthe ethanol removed on a rotovap
  7. washThe product was washed with water
  8. dry with materialdried with MgSO4
  9. distillationfractionally distilled

출처 및 근거

ORD 기록
ord-c161b0f5c00a47508e39a5ff3958dd94
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472227B1

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