Ozone → HCID 85753990, 화합물

HRID 992838노트

반응식

HRID 992838 반응식
[CH3:1][CH2:2][CH2:3][CH:4]([C:6]1([CH2:15][CH:16]=C)[C:13](=[O:14])[N-:12][C:10](=[O:11])[NH:9][C:7]1=[O:8])[CH3:5].[Na+].[O:19]=[O+][O-]>CO>[CH3:5][CH:4]([C:6]1([CH2:15][CH:16]=[O:19])[C:7](=[O:8])[NH:9][C:10](=[O:11])[NH:12][C:13]1=[O:14])[CH2:3][CH2:2][CH3:1]

참가 물질

4

반응물 2

HCID 24823OzoneHCID 14148199309-43-3

생성물 1

HCID 85753990HCID 85753990, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of sodium secobarbital (5.30 g, 22.2 mmol) in methanol was passed a stream of ozone until the solution turned a blue color. After excess ozone was removed by passing nitrogen through the reaction dimethyl sulfide (14 mL) was added. The reaction was stirred at room temperature overnight before solvents were removed on a rotovap. The aldehyde was then purified on silica prep plates using ethyl acetate:hexanes (1:1).

후처리

  1. customAfter excess ozone was removed
  2. customthrough the reaction dimethyl sulfide (14 mL)
  3. additionwas added
  4. customwere removed on a rotovap
  5. customThe aldehyde was then purified on silica prep plates

출처 및 근거

ORD 기록
ord-297627d4a007406daa837cbd3758e511
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472227B1

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