Urea → 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(3-methyl-2-butenyl)-
반응식
[Na].[NH2:2][C:3]([NH2:5])=[O:4].[CH2:6]([CH:11]([C:17](OCC)=[O:18])[C:12](OCC)=[O:13])[CH:7]=[C:8]([CH3:10])[CH3:9]>C(O)C>[CH3:9][C:8]([CH3:10])=[CH:7][CH2:6][CH:11]1[C:12](=[O:13])[NH:5][C:3](=[O:4])[NH:2][C:17]1=[O:18]참가 물질
5
실험 절차
To a solution of 70 mg sodium (3.03 mmol) in 1.0 mL absolute ethanol was added 61 mg urea (1.01 mmol), followed by 200 mg of the diethyl prenylmalonate (0.88 mmol) prepared in the previous experiment. The solution was refluxed gently for 12 hours. Most of the ethanol was removed by rotary evaporation, and the residue was diluted in water. The solution was acidified to pH 3 and extracted 2×10 mL with ethyl acetate. The combined organic phases were dried over anhydrous magnesium sulfate and concentrated to 214 mg of an off-white solid.
후처리
- customprepared in the previous experiment
- temperatureThe solution was refluxed gently for 12 hours
- customMost of the ethanol was removed by rotary evaporation
- additionthe residue was diluted in water
- extractionextracted 2×10 mL with ethyl acetate
- dry with materialThe combined organic phases were dried over anhydrous magnesium sulfate
- concentrationconcentrated to 214 mg of an off-white solid
출처 및 근거
- ORD 기록
- ord-aa3e50c6ae8d4c82bcfc4144ca17bec9
- 출처 데이터셋
- uspto-grants-2002_10
- 특허 번호
- US06472227B1
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