1-(2-Hydroxyethyl)piperazine → 5-[3-(4-Methoxyphenyl)propyl]-5-[4-(2-hydroxyethyl)piperazinyl]barbituric Acid

HRID 993054노트

반응식

HRID 993054 반응식
Br[C:2]1([CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[C:7](=[O:8])[NH:6][C:5](=[O:9])[NH:4][C:3]1=[O:10].[OH:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>C(O)C>[CH3:21][O:20][C:17]1[CH:18]=[CH:19][C:14]([CH2:13][CH2:12][CH2:11][C:2]2([N:28]3[CH2:29][CH2:30][N:25]([CH2:24][CH2:23][OH:22])[CH2:26][CH2:27]3)[C:7](=[O:8])[NH:6][C:5](=[O:9])[NH:4][C:3]2=[O:10])=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 184086795-Bromo-5-[3-(4-methoxyphenyl)propyl]barbituric acid

생성물 1

HCID 184086745-[3-(4-Methoxyphenyl)propyl]-5-[4-(2-hydroxyethyl)piperazinyl]barbituric Acid수율 3.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A of 5-Bromo-5-[3-(4-Methoxyphenyl)propyl]barbituric Acid (710 mg) and N-(2-hydroxyethyl)piperazine (281 mg) in 25 ml of ethanol is refluxed for 4 hours. The solvent is evaporated under reduced pressure and the residue is partitioned between 1 N hydrochloric acid and ethyl acetate. The aqueous phase is basified to pH=6-7 and extracted with ethyl acetate. The organic phase is concentrated to dryness and the residue is crystallized from ethyl acetate to give 30 mg of the product.

후처리

  1. customThe solvent is evaporated under reduced pressure
  2. customthe residue is partitioned between 1 N hydrochloric acid and ethyl acetate
  3. extractionextracted with ethyl acetate
  4. concentrationThe organic phase is concentrated to dryness
  5. customthe residue is crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-06b3964bb09e48b6a4ec998ca2b1d46c
출처 데이터셋
uspto-grants-2002_10
특허 번호
US06472396B1

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