Sodium ion → 2-(4-fluorophenyl)-4-tosyloxy-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

HRID 100209Notes

Reaction equation

HRID 100209 reaction equation
[F:18][c:19]1[cH:20][cH:21][c:22](-[n:23]2[c:24](=[O:25])[c:26]([O:27][CH3:28])[c:29](-[c:30]3[cH:31][cH:32][c:33]([S:34][CH3:35])[cH:36][cH:37]3)[cH:38][n:39]2)[cH:40][cH:41]1.[F:1][c:2]1[cH:3][cH:4][c:5](-[n:6]2[c:7](=[O:8])[c:9]([O:10][CH3:11])[c:12]([Br:13])[cH:14][n:15]2)[cH:16][cH:17]1.[F:42][c:43]1[cH:44][cH:45][c:46](-[n:49]2[n:50][cH:51][c:52](-[c:57]3[cH:58][cH:59][c:60]([S:63](=[O:64])(=[O:65])[CH3:66])[cH:61][cH:62]3)[c:53]([OH:56])[c:54]2=[O:55])[cH:47][cH:48]1.[Na+:68].[OH-:67].[c:69]1([CH3:79])[cH:70][cH:71][c:72]([S:75](=[O:76])(=[O:77])[Cl:78])[cH:73][cH:74]1>>[F:42][c:43]1[cH:44][cH:45][c:46](-[n:49]2[n:50][cH:51][c:52](-[c:57]3[cH:58][cH:59][c:60]([S:63](=[O:64])(=[O:65])[CH3:66])[cH:61][cH:62]3)[c:53]([O:56][S:75]([c:72]3[cH:71][cH:70][c:69]([CH3:79])[cH:74][cH:73]3)(=[O:76])=[O:77])[c:54]2=[O:55])[cH:47][cH:48]1

Participants

7

Reactant 6

HCID 923Sodium ionHCID 961HydroxideHCID 73974-Toluenesulfonyl chlorideHCID 14874955-bromo-2-(4-fluorophenyl)-4-methoxy-3(2H)-pyridazinoneHCID 219341922-(4-Fluorophenyl)-4-methoxy-5-[4-(methylthio)phenyl]-3(2H)-pyridazinoneHCID 178504687HCID 178504687, compound

Product 1

HCID 219338542-(4-fluorophenyl)-4-tosyloxy-5-[4-(methylsulfonyl)phenyl]-3(2H)-pyridazinone

Sources & evidence

ORD record
ord-a4b08ef7db5340dd8ab733f5b6d288ca
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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