2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthalene → (3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine

HRID 100235Notes

Reaction equation

HRID 100235 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([OH:21])[CH:11]([c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[Cl:22][CH2:23][c:24]1[cH:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[c:32]([O:34][CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:40])([CH3:41])[CH3:42])[cH:33]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([O:21][CH2:23][c:24]2[cH:25][c:26]3[cH:27][cH:28][cH:29][cH:30][c:31]3[c:32]([O:34][CH2:35][O:36][CH2:37][CH2:38][Si:39]([CH3:40])([CH3:41])[CH3:42])[cH:33]2)[CH:11]([c:14]2[cH:15][cH:16][c:17]([F:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 221265292-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthaleneHCID 22126857(3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ol

Product 1

HCID 22127049(3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-piperidine

Sources & evidence

ORD record
ord-b37ac26fea564d78ab439912144f10cf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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