Water → HCID 10856842, compound

HRID 1003130Notes

Reaction equation

HRID 1003130 reaction equation
[BH4-].[Na+].[CH2:3]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](=[O:16])[C:12]([F:15])([F:14])[F:13])[CH3:4].O>C(O)C>[CH2:3]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([OH:16])[C:12]([F:14])([F:15])[F:13])[CH3:4]

Participants

5

Reactant 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 11085102HCID 11085102, compound

Product 1

HCID 10856842HCID 10856842, compoundYield 93.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.6 g (0.07 mol) of sodium borohydride was added gradually to a solution of 30 g (0.14 mol) of 7-ethoxy-1,1,1-trifluoro-2-heptanone in 200 ml of ethanol at 0° C. The solution was stirred for 24 hours at room temperature. 200 ml of water was added and extracted with diethyl ether. The organic layer was washed with a small amount of water, dried over anhydrous magnesium sulfate and concentrated. The residue was distilled under the reduced pressure, to obtain 28 g of racemic 7-ethoxy-1,1,1-trifluoro-2-heptanol. Boiling point; 133-137° C. (50 mmHg).

Workup

  1. extractionextracted with diethyl ether
  2. washThe organic layer was washed with a small amount of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated
  5. distillationThe residue was distilled under the reduced pressure

Sources & evidence

ORD record
ord-5f993e51b58143aa85dcbc013f9dfbd4
Source dataset
uspto-grants-2000_04
Patent number
US06045720

Reaction notes

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