Trimethyl borate → HCID 18795258, compound

Participants

Reaction Conditions

Reaction Steps

9 ml of n-butyl lithium (1.68M hexane solution) was added dropwise to a solution of 5 g of 5-heptyl-2-(4-bromophenyl) pyridine prepared by the method described in Toku-Kai-Sho 60-163864 in 100 ml of THF with maintaining at -60° C. After stirring for 30 minutes with maintaining at -60° C., 3 g of trimethyl borate was added and stirred for further 1 hour. After the inner temperature was recovered gradually to the room temperature, 40 ml of 6N hydrochloric acid was added and then THF was distilled off. The formed solid was filtered and recrystallized, to obtain 3 g of 4-(5-heptylpyridin-2-yl)phenyl boronic acid. Melting point; 206-214° C.

Provenance & Evidence