Hydrochloric Acid → HCID 18795260, compound

HRID 1003132Notes

Reaction equation

HRID 1003132 reaction equation
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24]C(C#N)=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)=[CH:10][N:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[OH-:28].[Na+].Cl.C(O)CO[CH2:34][CH2:35][OH:36]>>[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][C:34]([C:35]([OH:36])=[O:28])=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)=[CH:10][N:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8117Diethylene GlycolHCID 14798Sodium HydroxideHCID 18795245HCID 18795245, compound

Product 1

HCID 18795260HCID 18795260, compound

Procedure

0.5 g (1.4 mmol) of 4'-(2-heptylpyridin-5-yl)-4-cyanobiphenyl and 0.5 g of sodium hydroxide were added to 20 ml of diethylene glycol and refluxed for 12 hours. By adding 200 ml of a 3% aqueous hydrochloric acid solution to the reaction solution, crystals were precipitated, separated by filtration and dried with air. The solid was recrystallized from acetic acid, to obtain 0.5 g of 4'-(2-heptylpyridin-5-yl)-4-biphenyl carboxylic acid. The melting thereof was above 250° C.

Workup

  1. temperaturerefluxed for 12 hours
  2. customwere precipitated
  3. customseparated by filtration
  4. customdried with air
  5. customThe solid was recrystallized from acetic acid

Sources & evidence

ORD record
ord-11a74da6660f4508ae6da63c7301b95d
Source dataset
uspto-grants-2000_04
Patent number
US06045720

Reaction notes

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