HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(2-Bromobutyryl)-glycine benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Bromobutanoyl chloride | HCID 90734 | — |
| Reactant | O-benzylglycine toluene-p-sulphonate | HCID 6451311 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-Bromobutyryl)-glycine benzyl ester | HCID 18795314 | — |
Reaction Steps
65.96 g (355.7 mmol) of α-bromobutyric acid chloride is added in drops at 0° C. to 100 g (296.4 mmol) of glycine benzyl ester p-toluenesulfonic acid salt and 89.98 g (889.2 mmol) of triethylamine in 500 ml of methylene chloride. In this case, the temperature remains between 0° C.-5° C. 1000 ml of 5% aqueous hydrochloric acid is added, and the organic phase is separated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06045776 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-27e2d386281b424f83487e15daa7a6e7 |
| Source note | uspto-grants-2000_04 |