Hydrochloric Acid → N-(2-Bromobutyryl)-glycine benzyl ester

HRID 1003138Notes

Reaction equation

HRID 1003138 reaction equation
[Br:1][CH:2]([CH2:6][CH3:7])[C:3](Cl)=[O:4].C1(C)C=CC(S(O)(=O)=O)=CC=1.[CH2:19]([O:26][C:27](=[O:30])[CH2:28][NH2:29])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C.Cl>C(Cl)Cl>[CH2:19]([O:26][C:27](=[O:30])[CH2:28][NH:29][C:3](=[O:4])[CH:2]([Br:1])[CH2:6][CH3:7])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 8471TriethylamineHCID 907342-Bromobutanoyl chlorideHCID 6451311O-benzylglycine toluene-p-sulphonate

Product 1

HCID 18795314N-(2-Bromobutyryl)-glycine benzyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

65.96 g (355.7 mmol) of α-bromobutyric acid chloride is added in drops at 0° C. to 100 g (296.4 mmol) of glycine benzyl ester p-toluenesulfonic acid salt and 89.98 g (889.2 mmol) of triethylamine in 500 ml of methylene chloride. In this case, the temperature remains between 0° C.-5° C. 1000 ml of 5% aqueous hydrochloric acid is added, and the organic phase is separated.

Workup

  1. customremains between 0° C.-5° C
  2. customthe organic phase is separated

Sources & evidence

ORD record
ord-27e2d386281b424f83487e15daa7a6e7
Source dataset
uspto-grants-2000_04
Patent number
US06045776

Reaction notes

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