反应详情

To a solution of estrone (11, 8.10 g, 30.0 mmol) in DMF (25 mL) were added imidazole (3.07 g, 45 mmol) and tert-butyldimethyl-chlorosilane (5.42 g, 36 mmol) at room temperature. The reaction mixture was stirred for 18 h, and then quenched with H2O (100 mL). The precipitate was collected by filtration and washed with H2O to afford 11.4 g of 29 (99% yield) mp: 171-172° C.

1. customquenched with H2O (100 mL)
2. filtrationThe precipitate was collected by filtration
3. washwashed with H2O