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HRID1003233

反应详情

EQUATION

反应方程式

HRID 1003233 的结构方程式

REACTANTS

反应物

2
结构：C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID5881

Dehydroepiandrosterone

C19H28O2

结构：CC(C)[C@@H]1CC(O)OC([C@@H](C)[C@H]2CC(=O)[C@@H]3[C@@H]4CCC5CC(O)CC[C@]5(C)[C@H]4CC[C@]23C)C1
HCID69625815

未命名化合物

PRODUCTS

生成物

2
结构：C[C@]12CC[C@H](O)CC1=CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12
HCID5881

Dehydroepiandrosterone

C19H28O2

结构：[C].[C]
HCID178420941

未命名化合物

PROCEDURE

实验过程

The synthesis of 22,29-epoxy-3,29-dihydroxy-14,-stigmastan-15-one (260) can be accomplished in ten steps from dehydroisoandrosterone (247). Catalytic hydrogenation of the Δ5 carbon-carbon double bond in compound 247 yields compound 250, which contains a trans-fused A/B ring-system. Compound 247 is dissolved in EtOAc and 10% Pd/C is added. The mixture is stirred under H2 at room temperature overnight. Filtration through celite and concentration yields compound 250, which can be used directly in the next reaction.

WORKUP

后处理

  1. customThe synthesis of 22,29-epoxy-3,29-dihydroxy-14