反应详情

A solution of 2.09 g of N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide in 57% hydriodic acid was stirred at 120° C. for 30 minutes. The reaction solution was diluted with water and extracted with chloroform. The chloroform layer was washed with a saturated aqueous solution of sodium hydrogen carbonate and a saturated aqueous solution of sodium chloride, then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue thus obtained was chromatographed over a silica gel column to afford 1.94 g of the title compound.

1. extractionextracted with chloroform
2. washThe chloroform layer was washed with a saturated aqueous solution of sodium hydrogen carbonate
3. dry with materiala saturated aqueous solution of sodium chloride, then dried over anhydrous magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure
5. customthe residue thus obtained
6. customwas chromatographed over a silica gel column