反应详情

To a solution of 419 mg of N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide in 20 ml of toluene was added 0.60 ml of a 47% hydrobromic acid and the mixture was heated under reflux for one hour. The reaction solution was washed successively with water, a saturated aqueous solution of sodium hydrogen carbonate and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the residue thus obtained was chromatographed over a silica gel column to afford 400 mg of the title compound.

1. temperaturethe mixture was heated
2. temperatureunder reflux for one hour
3. washThe reaction solution was washed successively with water
4. dry with materiala saturated aqueous solution of sodium hydrogen carbonate and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate
5. distillationThe solvent was distilled off under reduced pressure
6. customthe residue thus obtained
7. customwas chromatographed over a silica gel column