反应详情

To 170 mg of 12-iodododecylamine hydroiodide were added 120 mg of sodium 6-(4-ethyl-1-piperazinyl)-pyridine-3-carboxylate, 10 ml of methylene chloride, 95 mg of 1,3-dicyclohexylcarbodiimide (DCC) and 12 mg of 1-hydroxybenzotriazole (HOBt) and the mixture was stirred at room temperature for 3 hours. Insolubles were filtered off and the filtrate was chromatographed over a silica gel column to afford 169.5 mg of the title compound.

1. filtrationInsolubles were filtered off
2. customthe filtrate was chromatographed over a silica gel column