HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → N-(12-Iodododecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 12-Iodododecylamine hydroiodide | HCID 18796427 | — |
| Reactant | Sodium 6-(4-ethylpiperazinyl)pyridine-3-carboxylate | HCID 23663821 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(12-Iodododecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide | HCID 15462630 | 82.8% |
Reaction Steps
To 170 mg of 12-iodododecylamine hydroiodide were added 120 mg of sodium 6-(4-ethyl-1-piperazinyl)-pyridine-3-carboxylate, 10 ml of methylene chloride, 95 mg of 1,3-dicyclohexylcarbodiimide (DCC) and 12 mg of 1-hydroxybenzotriazole (HOBt) and the mixture was stirred at room temperature for 3 hours. Insolubles were filtered off and the filtrate was chromatographed over a silica gel column to afford 169.5 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06046201 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-3c7d15cbda4a4f7a90e4db58bf0ba3d8 |
| Source note | uspto-grants-2000_04 |