反应详情

To a solution of 72 mg of N-(12-mesyloxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide in acetone was added 130 mg of sodium iodide and the mixture was heated under reflux for 10 hours. To the reaction solution were added water and chloroform and extracted with chloroform. The chloroform layer was washed with a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was then distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford 69.0 mg of the title compound.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 10 hours
3. extractionextracted with chloroform
4. washThe chloroform layer was washed with a saturated aqueous solution of sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationThe solvent was then distilled off under reduced pressure
7. customThe residue thus obtained
8. customwas chromatographed over a silica gel column