反应详情

To a solution of 1.26 g of N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide in 20 ml of chloroform were added 4.2 ml of triethylamine, 5 ml of pyridine and 1.0 ml of mesyl chloride and the mixture was stirred at room temperature for 30 minutes. The reaction solution was washed successively with water, 3N-hydrochloric acid and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue thus obtained was chromatographed over a silica gel column to afford 1.11 g of the title compound.

1. washThe reaction solution was washed successively with water, 3N-hydrochloric acid
2. dry with materiala saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customthe residue thus obtained
5. customwas chromatographed over a silica gel column