1-Ethylpiperazine → N-(12-hydroxydodecyl)-6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide

Participants

Reaction Conditions

Reaction Steps

To 0.6 g of N-(12-hydroxydodecyl)-6-chloropyridine-3-carboxamide was added 5 ml of 1-ethylpiperazine and the mixture was stirred at 160° C. for 30 minutes. The reaction solution was diluted with chloroform, washed with water, dried over anhydrous sodium sulfate and distilled off under reduced pressure. The residue was chromatographed over a silica gel column to afford the title compound.

Provenance & Evidence