反应详情

温度

160 °C

To 0.6 g of N-(12-hydroxydodecyl)-6-chloropyridine-3-carboxamide was added 5 ml of 1-ethylpiperazine and the mixture was stirred at 160° C. for 30 minutes. The reaction solution was diluted with chloroform, washed with water, dried over anhydrous sodium sulfate and distilled off under reduced pressure. The residue was chromatographed over a silica gel column to afford the title compound.

1. washwashed with water
2. dry with materialdried over anhydrous sodium sulfate
3. distillationdistilled off under reduced pressure
4. customThe residue was chromatographed over a silica gel column