HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1003302Generated: October 26, 2026
1-Ethylpiperazine → 6-(4-Ethylpiperazin-1-yl)nicotinamide
https://huagongshe.com/reaction/1003302
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Ethylpiperazine | HCID 79196 | — |
| Reactant | 6-Chloronicotinamide | HCID 80456 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(4-Ethylpiperazin-1-yl)nicotinamide | HCID 18796430 | — |
Reaction Steps
A mixture of 0.5 g of 6-chloronicotinamide and 3 ml of 1-ethylpiperazine was stirred at 110° C. for 2 hours. The reaction solution was diluted with ethyl acetate, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to afford 0.10 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06046201 |
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| Source dataset | uspto-grants-2000_04 |
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| ORD ID | ord-d38d48acec374975abb82fa349494599 |
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| Source note | uspto-grants-2000_04 |
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