1-Ethylpiperazine → 6-(4-Ethylpiperazin-1-yl)nicotinamide

HRID 1003302Notes

Reaction equation

HRID 1003302 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][N:3]=1.[CH2:11]([N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)[CH3:12]>C(OCC)(=O)C>[CH2:11]([N:13]1[CH2:18][CH2:17][N:16]([C:2]2[N:3]=[CH:4][C:5]([C:6]([NH2:8])=[O:7])=[CH:9][CH:10]=2)[CH2:15][CH2:14]1)[CH3:12]

Participants

4

Reactant 2

HCID 791961-EthylpiperazineHCID 804566-Chloronicotinamide

Product 1

HCID 187964306-(4-Ethylpiperazin-1-yl)nicotinamide

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
110 °C

Procedure

A mixture of 0.5 g of 6-chloronicotinamide and 3 ml of 1-ethylpiperazine was stirred at 110° C. for 2 hours. The reaction solution was diluted with ethyl acetate, washed with water and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to afford 0.10 g of the title compound.

Workup

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-d38d48acec374975abb82fa349494599
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

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