反应详情

温度

70 °C

To a suspension of 0.055 g of 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxamide, 0.011 g of tetrabutylammonium hydrogen sulfate, 0.11 g of sodium hydroxide and 0.05 g of potassium carbonate in 3 ml of toluene was added dropwise at 70° C. a solution of 12-bromododecanol in 2 ml of toluene and the mixture was stirred at 70° C. for 13 hours. The reaction solution was diluted with chloroform, washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The residue thus obtained was chromatographed over a silica gel column to afford 0.025 g of the title compound.

1. washwashed with water
2. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
3. distillationThe solvent was distilled off under reduced pressure
4. customThe residue thus obtained
5. customwas chromatographed over a silica gel column