Chloroform → 12-Iodododecylamine hydroiodide
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]O.C(Cl)(Cl)Cl.[IH:19]>>[IH:19].[I:19][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][NH2:1]Participants
4
Procedure
An aqueous solution of 100 mg of 12-aminododecanol in 57% hydriodic acid was heated under reflux for one hour. To the reaction solution was added chloroform and the mixture was washed successively with water, a 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate. The solvent was distilled off and the residue thus obtained was chromatographed over a silica gel column to afford 171 mg of the title compound.
Workup
- temperatureunder reflux for one hour
- washthe mixture was washed successively with water
- dry with materiala 10% aqueous solution of sodium thiosulfate and a saturated aqueous solution of sodium chloride and then dried over anhydrous magnesium sulfate
- distillationThe solvent was distilled off
- customthe residue thus obtained
- customwas chromatographed over a silica gel column
Sources & evidence
- ORD record
- ord-8c38f6e4b61b4f4e9b472ebd6d0b9738
- Source dataset
- uspto-grants-2000_04
- Patent number
- US06046201
Reaction notes
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