反应详情

To a suspension of 5.0 g of tert-butyl N-(12-hydroxydodecyl)carbamate in 25 ml of methanol was added 3 ml of hydrochloric acid and the mixture was heated under reflux for one hour. The reaction solution was distilled off under reduced pressure, ethyl acetate was added to the residue, the crystal thus precipitated out was recovered by filtration and dried under reduced pressure to afford 3.23 g of the title compound.

1. temperaturethe mixture was heated
2. temperatureunder reflux for one hour
3. distillationThe reaction solution was distilled off under reduced pressure, ethyl acetate
4. additionwas added to the residue
5. customthe crystal thus precipitated out
6. filtrationwas recovered by filtration
7. customdried under reduced pressure