Hydrochloric Acid → 12-Amino-1-dodecanol Hydrochloride

HRID 1003311Notes

Reaction equation

HRID 1003311 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14]C(=O)OC(C)(C)C.[ClH:22]>CO>[ClH:22].[NH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][OH:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 3613308Tert-butyl N-(12-hydroxydodecyl)carbamate

Product 1

HCID 1851282612-Amino-1-dodecanol Hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 5.0 g of tert-butyl N-(12-hydroxydodecyl)carbamate in 25 ml of methanol was added 3 ml of hydrochloric acid and the mixture was heated under reflux for one hour. The reaction solution was distilled off under reduced pressure, ethyl acetate was added to the residue, the crystal thus precipitated out was recovered by filtration and dried under reduced pressure to afford 3.23 g of the title compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for one hour
  3. distillationThe reaction solution was distilled off under reduced pressure, ethyl acetate
  4. additionwas added to the residue
  5. customthe crystal thus precipitated out
  6. filtrationwas recovered by filtration
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-a30394c09aba4edc91cc04bf8d2f0e96
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

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