Water → Potassium 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylate

HRID 1003317Notes

Reaction equation

HRID 1003317 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[N:14]=[CH:13][C:12]([C:15]([O:17]CC)=[O:16])=[CH:11][CH:10]=2)[CH2:5][CH2:4]1)[CH3:2].[OH-].[K+:21].O.C(O)(C)C>CO>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[N:14]=[CH:13][C:12]([C:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)[CH2:7][CH2:8]1)[CH3:2].[K+:21]

Participants

6

Reactant 4

HCID 962WaterHCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 18796410Ethyl 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylate

Product 1

HCID 23663822Potassium 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylateYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To a solution of 69.81 g of ethyl 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylate in 280 ml of methanol were added 37 g of potassium hydroxide and a small volume of water and the mixture was heated under reflux for one hour. To the reaction solution were added methanol and isopropyl alcohol, the crystal thus precipitated out was recovered by filtration and then dried under reduced pressure to afford 70.65 g of the title compound as a colorless crystal.

Workup

  1. temperatureunder reflux for one hour
  2. customthe crystal thus precipitated out
  3. filtrationwas recovered by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-f2378e894660475cae36575a03adf7cf
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

Loading…