1-Ethylpiperazine → Methyl 6-(4-ethylpiperazin-1-yl)nicotinate

Participants

Reaction Steps

To 100 g of 1-ethylpiperazine warmed to 80° C. was added at 80-100° C. with stirring 50 g of methyl 6-chloropyridine-3-carboxylate. To the reaction solution was added 0.5 1 of water and the mixture was stirred. The crystal thus precipitated out was recovered by filtration, dried under reduced pressure to afford 68.8 g of the title compound as a crystal.

Provenance & Evidence