反应详情

To 100 g of 1-ethylpiperazine warmed to 80° C. was added at 80-100° C. with stirring 50 g of methyl 6-chloropyridine-3-carboxylate. To the reaction solution was added 0.5 1 of water and the mixture was stirred. The crystal thus precipitated out was recovered by filtration, dried under reduced pressure to afford 68.8 g of the title compound as a crystal.

1. additionwas added at 80-100° C.
2. customThe crystal thus precipitated out
3. filtrationwas recovered by filtration
4. customdried under reduced pressure