1-Ethylpiperazine → Ethyl 6-(4-ethyl-1-piperazinyl)pyridine-3-carboxylate

Participants

Reaction Conditions

Reaction Steps

To 55.69 g of ethyl 6-chloropyridine-3-carboxylate was added 115 ml of 1-ethylpiperazine and the mixture was heated with stirring (55-137° C.) for 5 minutes. After completion of the reaction, the 1-ethylpiperazine was distilled off under reduced pressure, the residue was crystallized from water-metanol. The crystal was washed with water and then dried under reduced pressure to afford 71.89 g of the title compound as a colorless crystal.

Provenance & Evidence