反应详情

温度

96 °C

To 55.69 g of ethyl 6-chloropyridine-3-carboxylate was added 115 ml of 1-ethylpiperazine and the mixture was heated with stirring (55-137° C.) for 5 minutes. After completion of the reaction, the 1-ethylpiperazine was distilled off under reduced pressure, the residue was crystallized from water-metanol. The crystal was washed with water and then dried under reduced pressure to afford 71.89 g of the title compound as a colorless crystal.

1. temperaturethe mixture was heated
2. customAfter completion of the reaction
3. distillationthe 1-ethylpiperazine was distilled off under reduced pressure
4. customthe residue was crystallized from water-metanol
5. washThe crystal was washed with water
6. customdried under reduced pressure