Hydrochloric Acid → 1-Isopropylpiperazine

HRID 1003323Notes

Reaction equation

HRID 1003323 reaction equation
C([N:3]1[CH2:8][CH2:7][N:6]([CH:9]([CH3:11])[CH3:10])[CH2:5][CH2:4]1)=O.Cl.O>CO>[CH:9]([N:6]1[CH2:7][CH2:8][NH:3][CH2:4][CH2:5]1)([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 18796408HCID 18796408, compound

Product 1

HCID 780131-IsopropylpiperazineYield 42%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 0.29 g of 1-formyl-4-isopropylpiperazine in 10 ml of methanol were added 0.5 ml of hydrochloric acid and 1 ml of water and the mixture was heated under reflux for 2 hours. The reaction solution was distilled off under reduced pressure, a iN aqueous solution of sodium hydroxide was added and the mixture was extracted with chloroform and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to afford 0.1 g of the title compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 hours
  3. distillationThe reaction solution was distilled off under reduced pressure
  4. additiona iN aqueous solution of sodium hydroxide was added
  5. extractionthe mixture was extracted with chloroform
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-b4fdd7e6fdb5445c830c92446479e69f
Source dataset
uspto-grants-2000_04
Patent number
US06046201

Reaction notes

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