反应详情

Fusaric acid (2 g), diphenylphosphoryl azide (2.4 mL) and triethylamine (1.6 mL) in t-butanol (70 mL) were refluxed overnight. The contents were concentrated in vacuo and treated with 25% aqueous HBr (20 mL) for 24 hours. After neutralizing with 50% NaOH, contents were extracted with CH2Cl2, dried (MgSO4) and concentrated in vacuo to give 2-amino-5-(n-butyl)pyridine as an oil (1.1 g).

1. concentrationThe contents were concentrated in vacuo
2. additiontreated with 25% aqueous HBr (20 mL) for 24 hours
3. extractionwere extracted with CH2Cl2
4. dry with materialdried (MgSO4)
5. concentrationconcentrated in vacuo