反应详情

2-chloro-6-methyl-4-(trifluoromethyl)pyridine (5.0 g) and conc ammonium hydroxide (150 mL) were heated at 180° C. in a steel reaction vessel with mechanical stirring overnight. The contents were allowed to cool and partitioned between CH2Cl2 and water. The CH2Cl2 layer was dried (MgSO4) and concentrated in vacuo leaving 2-amino-6-methyl-4-(trifluoromethyl)pyridine as a white solid.

1. temperatureto cool
2. custompartitioned between CH2Cl2 and water
3. dry with materialThe CH2Cl2 layer was dried (MgSO4)
4. concentrationconcentrated in vacuo