Sodium Hydroxide → HCID 136333564, compound

HRID 1003523Notes

Reaction equation

HRID 1003523 reaction equation
Cl.[NH2:2][OH:3].[OH-].[Na+].[CH:6]([C:8]1[N:17]=[C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]3[O:26][CH2:27][O:28][C:22]=3[CH:21]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:29])[CH:14]=2)[N:9]=1)=O>C(O)C>[OH:3][N:2]=[CH:6][C:8]1[N:17]=[C:16]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]3[O:26][CH2:27][O:28][C:22]=3[CH:21]=2)[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([Cl:29])[CH:14]=2)[N:9]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 18796731HCID 18796731, compound

Product 1

HCID 136333564HCID 136333564, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

0.60 g of hydroxylamine hydrochloride and 3.0 ml of a 1N aqueous solution of sodium hydroxide were added to a solution of 1.00 g (2.93 mmol) of 2-formyl-4-(3,4-methylenedioxybenzyl)amino-6-cloroquinazoline in 30 ml of ethanol. The obtained mixture was stirred at 60° C. for 30 minutes and cooled by allowing to stand. The crystal thus precipitated was recovered by filtration, washed with ethanol and n-hexane and air-dried to give 1.00 g of the title compound as a white crystal.

Workup

  1. temperaturecooled
  2. customThe crystal thus precipitated
  3. filtrationwas recovered by filtration
  4. washwashed with ethanol and n-hexane
  5. customair-dried

Sources & evidence

ORD record
ord-25382264258c4128a544676bc5d5c18c
Source dataset
uspto-grants-2000_04
Patent number
US06046206

Reaction notes

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