Acetone → HCID 86755284, compound

HRID 1003721Notes

Reaction equation

HRID 1003721 reaction equation
[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@@H:11]2[OH:18])[C:8]2[C:3](=[C:4]([NH2:20])[N:5]=[C:6]([F:19])[N:7]=2)[N:2]=1.[P:21]([O-:25])([O-:24])([O-:23])=[O:22].C(=O)([O-])[O-].[K+:30].[K+].CC(C)=O>O>[CH:1]1[N:9]([C@@H:10]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:12]([OH:17])[C@@H:11]2[OH:18])[C:8]2[C:3](=[C:4]([NH2:20])[N:5]=[C:6]([F:19])[N:7]=2)[N:2]=1.[K+:30].[K+:30].[P:21]([OH:25])([O-:24])([O-:23])=[O:22]

Participants

5

Reactant 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 86755285HCID 86755285, compound

Product 1

HCID 86755284HCID 86755284, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.0 g of fludarabine-phosphate at a purity of 96.1% is dissolved in 30 ml of water, and 6.5 ml of a potassium carbonate solution (18.5% by weight) is added to this solution below 30° C. It is stirred for 15 more minutes, then solid material is filtered out. The clear solution that is thus obtained is poured into acetone at 50° C., cooled to room temperature and stirred for 2 more hours. The deposited precipitate is filtered and washed twice with acetone. 4.5 g of fludarabine-phosphate dipotassium salt is obtained.

Workup

  1. filtrationsolid material is filtered out
  2. customThe clear solution that is thus obtained
  3. stirringstirred for 2 more hours
  4. filtrationThe deposited precipitate is filtered
  5. washwashed twice with acetone

Sources & evidence

ORD record
ord-2a2983dbc2084c9f825792565a60f7e4
Source dataset
uspto-grants-2000_04
Patent number
US06046322

Reaction notes

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