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HRID1003722

反应详情

EQUATION

反应方程式

HRID 1003722 的结构方程式

REACTANTS

反应物

2
结构：Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@@H]1O
HCID30751

Fludarabine phosphate

C10H13FN5O7P

结构：[Mg+2].[O-2]
HCID6850729

Magnesium oxide

MgO

PRODUCTS

生成物

1
结构：Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O.O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Mg+2].[Mg+2].[Mg+2]
HCID86755286

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

10.0 g of fludarabine phosphate at a purity of 97.5% is suspended in 100 ml of water within about 5 minutes, and magnesium oxide is added to this solution. The mixture is stirred for one more hour at room temperature and then filtered. The clear solution is poured into 200 ml of acetone, stirred for 1 more hour, and the crystallizate is separated by filtration. 10.0 g (95% of theory) of the fludarabine-phosphate magnesium salt is obtained.

WORKUP

后处理

  1. filtrationfiltered
  2. additionThe clear solution is poured into 200 ml of acetone
  3. stirringstirred for 1 more hour
  4. customthe crystallizate is separated by filtration