HCID 18798258, compound → HCID 18798245, compound

HRID 1003731Notes

Reaction equation

HRID 1003731 reaction equation
[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][C:19]=3[O:27][CH3:28])[CH2:14][CH2:13]2)=[C:6]([CH3:29])[C:5](=[O:30])[N:4]([CH3:31])[C:3]1=[O:32]>C(O)C.O.O.NN.[Ni]>[CH3:1][N:2]1[C:7]([NH:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[CH:23]=[CH:22][C:21]([NH2:24])=[CH:20][C:19]=3[O:27][CH3:28])[CH2:16][CH2:17]2)=[C:6]([CH3:29])[C:5](=[O:30])[N:4]([CH3:31])[C:3]1=[O:32]

Participants

4

Reactant 1

HCID 18798258HCID 18798258, compound

Product 1

HCID 18798245HCID 18798245, compound

Reagents, catalysts & solvents 2

HCID 86755287HCID 86755287, compoundCatalystHCID 19096565Water ethanolSolvent

Procedure

50 mmol of 1,3,5-trimethyl-6-[(3-[4-(2-methoxy-4-nitrophenyl)-1-piperazinyl]propyl)amino]-2,4(1H,3H)-pyrimidinedione are reduced using hydrazine hydrate/Raney-Nickel in ethanol/water according to a known method. After purification by column chromatography and recrystallization from ethyl acetate, 73% of the title compound of m.p. 146-148° C. is obtained. The starting substance is the product of Example 14.

Workup

  1. customAfter purification
  2. customby column chromatography and recrystallization from ethyl acetate, 73% of the title compound of m.p. 146-148° C.
  3. customis obtained

Sources & evidence

ORD record
ord-b509b3ef241f49668b4fe6c1e250054c
Source dataset
uspto-grants-2000_04
Patent number
US06046329

Reaction notes

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