Hydrochloric Acid → HCID 54052828, compound

HRID 1003744Notes

Reaction equation

HRID 1003744 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[F:18])[CH2:5][C:6]1[O:10]C=[N:8][C:7]=1[C:11]([O:13][CH3:14])=[O:12].Cl>CO>[CH3:14][O:13][C:11](=[O:12])[CH:7]([NH2:8])[C:6](=[O:10])[CH2:5][C:4]1[CH:15]=[CH:16][C:17]([F:18])=[C:2]([F:1])[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18798270HCID 18798270, compound

Product 1

HCID 54052828HCID 54052828, compoundYield 104.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
80 °C

Procedure

To 5-(3,4-difluorobenzyl)-4-methoxycarbonyloxazole (0.100 g, 0.393 mmol) in methanol (5 mL) was added 2 mL of 6N HCl, and the solution heated at 80° C. for 2 hours. The reaction mixture was concentrated to yield 0.100 g (88%) of a solid which was used as such for the subsequent step.

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-9b7c10a22e814ef88e89d6b933f93a39
Source dataset
uspto-grants-2000_04
Patent number
US06046331

Reaction notes

Loading…