反应详情

To a stirred and heated (80° C.) suspension of hydroxyzine hydrochloride (1.0 g, 2.23 mmol) and 5% Pt/C in dioxane (10 mL) and 1N aqueous NaOH solution (10 mL), O2 was bubbled through for 20 hours. After being cooled down to room temperature, The mixture was filtered through a pad of celite (2.5×2 cm) and washed with water. The filtrate was extracted with dichloromethane (3×25 mL). The combined organic solution was dried (Na2SO4). Evaporation of solvent gave the titled compound as a pale white form (0.51 g, yield 58.7%).

1. temperatureheated
2. customwas bubbled through for 20 hours
3. filtrationThe mixture was filtered through a pad of celite (2.5×2 cm)
4. washwashed with water
5. extractionThe filtrate was extracted with dichloromethane (3×25 mL)
6. dry with materialThe combined organic solution was dried (Na2SO4)
7. customEvaporation of solvent