2,4-Dichloropyrimidine → HCID 18327463, compound

HRID 1004041Notes

Reaction equation

HRID 1004041 reaction equation
[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[SH:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][CH:18]=1)[C:13]([OH:15])=[O:14]>C(O)C>[C:13]([C:12]1[CH:11]=[C:10]([S:9][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=2)[CH:18]=[CH:17][CH:16]=1)([OH:15])=[O:14]

Participants

4

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 95737Benzoic acid, 3-mercapto-

Product 1

HCID 18327463HCID 18327463, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(3-Carboxyphenylsulphanyl)-2-chloropyrimidine was prepared by heating a solution of 2,4-dichloropyrimidine (2.97 g, 19.9 mmol) and 3-mercaptobenzoic acid (3.07 g, 19.9 mmol) in ethanol (50 ml) at reflux for 1 h. On cooling to 0°, the resulting precipitate was collected and dried to give the desired material (3.38 g) as a white solid.

Workup

  1. temperatureat reflux for 1 h
  2. temperatureOn cooling to 0°
  3. customthe resulting precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-45476c22714147a2808cbe36d7f40b55
Source dataset
uspto-grants-2000_04
Patent number
US06048866

Reaction notes

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