Phenyl isocyanate → HCID 18794229, compound

HRID 1004050Notes

Reaction equation

HRID 1004050 reaction equation
[CH3:1][C:2]1[NH:16][CH2:15][CH2:14][C:4]2=[C:5]3[C:10](=[N:11][C:3]=12)[CH:9]=[CH:8][C:7]([O:12][CH3:13])=[CH:6]3.[C:17]1([N:23]=[C:24]=[O:25])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CCOCC>[CH2:1]=[C:2]1[C:3]2[NH:11][C:10]3[C:5](=[CH:6][C:7]([O:12][CH3:13])=[CH:8][CH:9]=3)[C:4]=2[CH2:14][CH2:15][N:16]1[C:24](=[O:25])[NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 178487038HCID 178487038, compound

Product 1

HCID 18794229HCID 18794229, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
45 °C

Procedure

To a solution of 10-methoxyharmalan in anhydrous ether is added phenyl isocyanate. The mixture is stirred for 1 h 30 and then heated at 45° C. for 30 min. The 1-methylene-2-(N-plienyl)carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline is recovered by filtration and then washed with ether.

Workup

  1. filtrationThe 1-methylene-2-(N-plienyl)carbamoyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline is recovered by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-a370981202824951af8000935864fe8d
Source dataset
uspto-grants-2000_04
Patent number
US06048868

Reaction notes

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